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Chemical Structure : SM1-71
Catalog No.: PC-72223Not For Human Use, Lab Use Only.
SM1-71 is a multi-targeted acrylamide-modified inhibitor that covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC (IC50=4 nM), YES1, FGFR1 (IC50=54 nM), ZAK (MLTK), MAP3K1, LIMK1 and RSK2.
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SM1-71 is a multi-targeted acrylamide-modified inhibitor that covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC (IC50=4 nM), YES1, FGFR1 (IC50=54 nM), ZAK (MLTK), MAP3K1, LIMK1 and RSK2.
| M.Wt | 463.97 | |
| Formula | C24H26ClN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rao S, et al. J Biol Chem. 2019 May 24;294(21):8664-8673.
2. Rao S, et al. Cell Chem Biol. 2019 Jun 20;26(6):818-829.e9.
3. Guangyan Du, et al. J Med Chem. 2020 Feb 27;63(4):1624-1641.
4. Gurbani D, et al. Front Mol Biosci. 2020 May 19;7:81.
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