Chemical Structure : SM15
CAS No.:
825602-13-9
SM15
Catalog No.: PC-27735Not For Human Use, Lab Use Only.
SM15 is a small molecule targeting microtubule-Hec1 interaction, inhibits cancer cell growth through microtubule stabilization, binds the MT surface independently from Hec1 and acts as a stabilizer of both microtubules (MTs) and kinetochore (KT)-microtubule (MT) interactions.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SM15 is a small molecule targeting microtubule-Hec1 interaction, inhibits cancer cell growth through microtubule stabilization, binds the MT surface independently from Hec1 and acts as a stabilizer of both microtubules (MTs) and kinetochore (KT)-microtubule (MT) interactions.
SM15 shows IC50 of 6.0 uM in HeLa cells.
SM15 binds to MTs with a higher affinity with respect to tubulin dimers (KD=0.94 uM and 1.80 uM, respectively).
SM15 induces arrested HeLa cells in the G2/M phases of the cell cycle efficiently.
SM15 induces cell death in tumor cell lines both by mitotic catastrophe and by apoptotic cell death directly from interphase.
SM15 (10 mg/kg) exerts anti-tumor activity, inhibits HeLa tumor growth in vivo.
Physicochemical Properties
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M.Wt
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467.41
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Formula
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C25H27BrN2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-1-(4-bromophenyl)-3-(1-(2-hydroxy-3-(piperidin-1-yl)propyl)-1H-indol-3-yl)prop-2-en-1-one
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References
1. Pellegrini FR, et al. Autophagy. 2023 Jul;19(7):2078-2093.
2. Ferrara M, et al. Oncogene. 2018 Jan 11;37(2):231-240.
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