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SM875

Chemical Structure : SM875

CAS No.: 919023-94-2

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SM875

Catalog No.: PC-24687Not For Human Use, Lab Use Only.

SM875 is a small molecule prion (PrP) protein degrader, decreases the levels of PrP in HEK293 cells with IC50 of 7.87 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SM875 is a small molecule prion (PrP) protein degrader, decreases the levels of PrP in HEK293 cells with IC50 of 7.87 uM.
SM875 (1-30 uM) decreased PrP levels in a dose-dependent fashion in human breast cancer cell line (ZR-75) endogenously expressing human PrP.
SM875 induces the degradation of PrP by the lysosomes. SM875 acts exclusively on non-native, newly synthesized PrP.
SM875 suppresses prion replication in mouse L929 fibroblasts, induces the aggregation of partially denatured PrP.

Physicochemical Properties

M.Wt 414.26
Formula C19H16BrN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-bromophenyl)-1,4,5,7-tetrahydro-4-(4-hydroxy-3)-6H-pyrazolo[3,4-b]pyridin-6-one

References

1. Spagnolli G, et al. Commun Biol. 2021 Jan 12;4(1):62.

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