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Chemical Structure : SMBA1
Catalog No.: PC-60925Not For Human Use, Lab Use Only.
SMBA1 is a potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.
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SMBA1 is a potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.
SMBA1 shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak.
SMBA1 facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells.
SMBA1 potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity.
| M.Wt | 315.32 | |
| Formula | C20H13NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xin M, et al. Nat Commun. 2014 Sep 17;5:4935.
2. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023.
3. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012.
4. Levesley J, et al. Neuro Oncol. 2017 Jul 20. doi: 10.1093/neuonc/nox134.
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