Chemical Structure : SMC18
CAS No.:
901022-20-6
SMC18
(SMC 18)
Catalog No.: PC-21925Not For Human Use, Lab Use Only.
SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
SMC18 binds SIRPα and PD-L1 to block CD47/SIRPα and PD-1/PD-L1 interaction.
SMC18 does not impede the hTIGIT/hPVR, hLAG-3/hFGL-1, hCD112R/hCD112, and hTIM-3/hGal-9 pathways.
SMC18 effectively enhances the macrophages-mediated phagocytosis of tumor cells.
SMC18 effectively inhibits the phosphorylation of PD-1 and restores T cell function.
SMC18 (6 mg/kg) significantly inhibits MC38 tumor growth and triggers antitumor immune response, shows no hematotoxicity and hepatotoxicity.
SMC18 exhibits synergistic inhibition of MC38 tumor growth by combining with radiotherapy.
Physicochemical Properties
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M.Wt
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475.56
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Formula
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C26H25N3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-[(3,5-dimethylphenyl)sulfamoyl]-4-oxo-N-(2-phenylethyl)-1,4-dihydroquinoline-3-carboxamide
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References
1. Jin S, et al. Cell Commun Signal. 2024 Mar 11;22(1):173.
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