Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SMC18
Catalog No.: PC-21925Not For Human Use, Lab Use Only.
SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
SMC18 binds SIRPα and PD-L1 to block CD47/SIRPα and PD-1/PD-L1 interaction.
SMC18 does not impede the hTIGIT/hPVR, hLAG-3/hFGL-1, hCD112R/hCD112, and hTIM-3/hGal-9 pathways.
SMC18 effectively enhances the macrophages-mediated phagocytosis of tumor cells.
SMC18 effectively inhibits the phosphorylation of PD-1 and restores T cell function.
SMC18 (6 mg/kg) significantly inhibits MC38 tumor growth and triggers antitumor immune response, shows no hematotoxicity and hepatotoxicity.
SMC18 exhibits synergistic inhibition of MC38 tumor growth by combining with radiotherapy.
| M.Wt | 475.56 | |
| Formula | C26H25N3O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Jin S, et al. Cell Commun Signal. 2024 Mar 11;22(1):173.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
