SMCC-DM1 |CAS:1228105-51-8 Probechem Biochemicals

Chemical Structure : SMCC-DM1

CAS No.: 1228105-51-8

Catalog No.: PC-42307Not For Human Use, Lab Use Only.

A thioether linker conjugated with potent microtubule-disrupting agent DM1 (mertansine)..

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Biological Activity

A thioether linker conjugated with potent microtubule-disrupting agent DM1 (mertansine).

M.Wt	1072.61164
Formula	C51H66ClN5O16S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Maytansine, N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-

1. Erickson HK, et al. Cancer Res. 2006 Apr 15;66(8):4426-33.

2. Ikeda H, et al. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.

3. Erickson HK, et al. Bioconjug Chem. 2010 Jan;21(1):84-92.

4. Kellogg BA, et al. Bioconjug Chem. 2011 Apr 20;22(4):717-27.