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SMER-18

Chemical Structure : SMER-18

CAS No.: 944153-47-3

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SMER-18 (SMER18)

Catalog No.: PC-45515Not For Human Use, Lab Use Only.

SMER-18 is a small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SMER-18 is a small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein.
SMER-18 reduces toxicity in Huntington's disease models.

Physicochemical Properties

M.Wt 287.7409
Formula C16H14ClNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

References

1. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.

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