SMER28 is a small-molecule enhancer/inducer of Autophagy, SMER28 is a small molecule activator of VCP/p97.
SMER28 decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
SMER28 enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.
Physicochemical Properties
M.Wt
264.1212
Formula
C11H10BrN3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 32 mg/mL
Chemical Name/SMILES
4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
References
1. Doulatov S, et al. Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645.
2. Rosenthal AK, et al. J Biol Chem. 2015 May 22;290(21):13028-38.
3. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.
