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Chemical Structure : SMIFH2
CAS No.: 340316-62-3
Catalog No.: PC-62426Not For Human Use, Lab Use Only.
SMIFH2 is a small molecule formin homology 2 domains inhibitor of formin-mediated actin assembly, targets formins from evolutionarily diverse organisms including yeast, nematode worm, and mice with IC50s of 5-15 uM.
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|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
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SMIFH2 is a small molecule formin homology 2 domains inhibitor of formin-mediated actin assembly, targets formins from evolutionarily diverse organisms including yeast, nematode worm, and mice with IC50s of 5-15 uM.
SMIFH2 prevents both formin nucleation and processive barbed end elongation and decreases formin's affinity for the barbed end.
SMIFH2 disrupts formin-dependent, but not Arp2/3 complex-dependent, actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts at low micromolar concentrations.
| M.Wt | 377.212 | |
| Formula | C15H9BrN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione |
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1. Rizvi SA, et al. Chem Biol. 2009 Nov 25;16(11):1158-68.
2. Ziske MA, et al. Biochem Biophys Res Commun. 2016 Mar 25;472(1):33-9.
3. Borinskaya S, et al. Mol Biol Cell. 2016 Jan 15;27(2):247-59.
4. Isogai T, et al. Sci Rep. 2015 Apr 30;5:9802.
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