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Chemical Structure : SMNDC1 inhibitor 28
Catalog No.: PC-21062Not For Human Use, Lab Use Only.
SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN.
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SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN.
SMNDC1 inhibitor 28 drastically alters protein-protein interactions and subcellular localization, causing splicing changes for SMNDC1-dependent genes.
| M.Wt | 466.56 | |
| Formula | C24H26N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lennart Enders, et al. Nat Commun. 2023 Aug 16;14(1):4504.
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