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SMP-114

Chemical Structure : SMP-114

CAS No.: 215174-50-8

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SMP-114 (Rimacalib, SMP114)

Catalog No.: PC-21505Not For Human Use, Lab Use Only.

SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis.
SMP-114 significantly reduces SR Ca2+ leak in human atrial and failing left ventricular as well as in murine ventricular cardiomyocytes.
SMP-114 demonstrates potential to treat SR Ca2+ leak and consequently proarrhythmogenic events in rodent as well as in human atrial cardiomyocytes and cardiomyocytes from patients with heart failure.

Physicochemical Properties

M.Wt 394.45
Formula C22H23FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N'-[3-[(1S)-1-(3-fluoro-4-phenylphenyl)ethyl]-1,2-oxazol-5-yl]morpholine-4-carboximidamide

References

1. Westra J, et al. Ann N Y Acad Sci. 2009 Sep;1173:706-11.

2. Neef S, et al. Basic Res Cardiol. 2017 Jul;112(4):45.

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