SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
SMT-738 shows potent in vitro activity across all the clinical isolates with MIC90 values of 1 µg/mL against E. coli and 2 µg/mL against K. pneumoniae.
SMT-738 displays potent antimicrobial activity against clinically relevant strains of Enterobacteriaceae and exerts its bactericidal activity via a mechanism distinct from that of known classes of antibiotics.
SMT-738 acts by disruption of LolCDE complex activity.
SMT-738 demonstrates robust efficacy in multiple murine in vivo infection models (bloodstream/pneumonia/urinary tract).
