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Chemical Structure : SMT-738
Catalog No.: PC-21552Not For Human Use, Lab Use Only.
SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
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SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
SMT-738 shows potent in vitro activity across all the clinical isolates with MIC90 values of 1 µg/mL against E. coli and 2 µg/mL against K. pneumoniae.
SMT-738 displays potent antimicrobial activity against clinically relevant strains of Enterobacteriaceae and exerts its bactericidal activity via a mechanism distinct from that of known classes of antibiotics.
SMT-738 acts by disruption of LolCDE complex activity.
SMT-738 demonstrates robust efficacy in multiple murine in vivo infection models (bloodstream/pneumonia/urinary tract).
| M.Wt | 392.46 | |
| Formula | C21H24N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent WO 2022/233886 A1
2. Breidenstein EBM, et al. Antimicrob Agents Chemother. 2023 Dec 12:e0069523.
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