Chemical Structure : SMT-738
CAS No.:
2862851-15-6
SMT-738
(SMT738)
Catalog No.: PC-21552Not For Human Use, Lab Use Only.
SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
SMT-738 shows potent in vitro activity across all the clinical isolates with MIC90 values of 1 µg/mL against E. coli and 2 µg/mL against K. pneumoniae.
SMT-738 displays potent antimicrobial activity against clinically relevant strains of Enterobacteriaceae and exerts its bactericidal activity via a mechanism distinct from that of known classes of antibiotics.
SMT-738 acts by disruption of LolCDE complex activity.
SMT-738 demonstrates robust efficacy in multiple murine in vivo infection models (bloodstream/pneumonia/urinary tract).
Physicochemical Properties
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M.Wt
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392.46
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Formula
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C21H24N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-amino-1-(6-(2-amino-5-(3-methylpyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-2-methylpropan-1-one
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References
1. Patent WO 2022/233886 A1
2. Breidenstein EBM, et al. Antimicrob Agents Chemother. 2023 Dec 12:e0069523.
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