Catalog No.: PC-20919Not For Human Use, Lab Use Only.
SMURF1 inhibitor Cpd-6 is a potent, specific E3 ubiquitin protein ligase 1 (SMURF1) inhibitor with biochemical IC50 of 11 nM, displays no activity against SMURF2.
SMURF1 inhibitor Cpd-6 is a potent, specific E3 ubiquitin protein ligase 1 (SMURF1) inhibitor with biochemical IC50 of 11 nM, displays no activity against SMURF2.
SMURF1 inhibitor Cpd-6 also is highly selective against an E3 ligase panel consisting of ubiquitin-protein ligase E3A (UBE3A/E6AP), WW domain-containing protein 1/NEDD4-like E3 ubiquitin-protein ligase (WWP1), WW domain-containing protein 2 (Wwp2), neural precursor cell expressed developmentally downregulated protein 4 (Nedd4), Itch.
SMURF1 inhibitor Cpd-6 shows a clean safety pharmacology profile against a standard panel of ion channels and GPCRs.
SMURF1 inhibitor Cpd-6 (10 mg/kg) exhibits in vivo efficacy in the hypoxia/Sugen rat model of pulmonary hypertension.
