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SN-013

Chemical Structure : SN-013

CAS No.: 2616665-67-7

SN-013 (SN013)

Catalog No.: PC-22730Not For Human Use, Lab Use Only.

SN-013 is a potent, selective STING inhibitor, inhibits 2′3′-cGAMP-induced Ifnb gene expression with IC50 of 101.5 nM and 539.6 nM in MEF and HFF cells, respectively, targets the cyclic dinucleotide binding pocket.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SN-013 is a potent, selective STING inhibitor, inhibits 2′3′-cGAMP-induced Ifnb gene expression with IC50 of 101.5 nM and 539.6 nM in MEF and HFF cells, respectively, targets the cyclic dinucleotide binding pocket.

Physicochemical Properties

M.Wt 382.43
Formula C20H18N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-hydroxy-3-(methylsulfonamido)phenyl)-[1,1'-biphenyl]-4-carboxamide

References

1. Hong Z, et al. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.

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