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SN-6109

Chemical Structure : SN-6109

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SN-6109 (SN6109)

Catalog No.: PC-72302Not For Human Use, Lab Use Only.

SN-6109 (SN6109) is a small molecule inhibitor RIPK-1 with IC50 of 0.45 uM in radiometric kinase assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SN-6109 (SN6109) is a small molecule inhibitor RIPK-1 with IC50 of 0.45 uM in radiometric kinase assays.
    SN-6109 reduced MLKL activation EC50 2.5-11.5 uM under long-term necroptosis execution in murine fibroblast L929 cells, and full protection from ATP depletion and membrane leakage in human and murine cells.
    SN-6109 decreased p-MLKL/MLKL and p-RIPK3/RIPK3 ratios in mouse liver tissue, showed efficacy in an in vivo model of tissue injury and inflammation driven by RIPK1/3-dependent cell death.

    Physicochemical Properties

    M.Wt 333.391
    Formula C20H19N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1-benzyl-1H-pyrazol-4-yl)(2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)methanone

    References

    1. Hugo Brito, et al. Cell Death Discov. 2020 Feb 11;6:6.

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