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SN79 dihydrochloride

Chemical Structure : SN79 dihydrochloride

CAS No.: 1121928-95-7

SN79 dihydrochloride (Sigma receptor ligand SN79)

Catalog No.: PC-35890Not For Human Use, Lab Use Only.

SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative sigma receptor (σ receptor) antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.
    SN79 shows activity against methamphetamine-induced neurotoxicity in vivo.
    SN79 blocks methamphetamine-induced microglial activation and cytokine upregulation.

    Physicochemical Properties

    M.Wt 484.393
    Formula C23H28Cl2FN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one dihydrochloride

    References

    1. Nicholson HE, et al. J Pharmacol Exp Ther. 2018 Dec 7. pii: jpet.118.253484. doi: 10.1124/jpet.118.253484.

    2. Kaushal N, et al. AAPS J. 2011 Sep;13(3):336-46. doi: 10.1208/s12248-011-9274-9.

    3. Seminerio MJ, et al. Eur J Pharmacol. 2012 Sep 15;691(1-3):103-9. doi: 10.1016/j.ejphar.2012.07.029.

    4. Kaushal N, et al. Eur J Pharmacol. 2014 Feb 5;724:193-203.

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