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SNAP-7941

Chemical Structure : SNAP-7941

CAS No.: 387825-78-7

SNAP-7941 (SNAP7941)

Catalog No.: PC-61528Not For Human Use, Lab Use Only.

SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM; inhibits food intake stimulated by central administration of MCH, reduces consumption of palatable food, decreases in body weight in rats with diet-induced obesity; also produces effects similar to clinically used antidepressants and anxiolytics in animal models of depression/anxiety.

Obesity

Discontinued

Physicochemical Properties

M.Wt 641.704
Formula C33H41F2N5O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methyl (6S)-1-[3-[4-(3-acetamidophenyl)piperidin-1-yl]propylcarbamoyl]-6-(3,4-difluorophenyl)-4-(methoxymethyl)-2-oxo-3,6-dihydropyrimidine-5-carboxylate

References

1. Borowsky B, et al. Nat Med. 2002 Aug;8(8):825-30.

2. Basso AM, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20.

3. Millan MJ, et al. Int J Neuropsychopharmacol. 2008 Dec;11(8):1105-22.

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