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SNAP-94847

Chemical Structure : SNAP-94847

CAS No.: 487051-12-7

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SNAP-94847 (SNAP94847)

Catalog No.: PC-61527Not For Human Use, Lab Use Only.

SNAP-94847 is a selective, high-affinity, and competitive MCH1 receptor (MCHR1) antagonist with Ki of 1.69 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SNAP-94847 is a selective, high-affinity, and competitive MCH1 receptor (MCHR1) antagonist with Ki of 1.69 nM.
    SNAP-94847 displays an anxiolytic/antidepressant-like effect in mouse models, stimulates the proliferation of progenitors in the dentate gyrus.
    SNAP-94847 has a unique anxiolytic-like profile that is distinct from selective serotonin reuptake inhibitors and tricyclic antidepressants.

    Physicochemical Properties

    M.Wt 478.572
    Formula C29H32F2N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide

    References

    1. David DJ, et al. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48.

    2. Chen CA, et al. J Med Chem. 2007 Aug 9;50(16):3883-90.

    3. Nair SG, et al. Psychopharmacology (Berl). 2009 Jul;205(1):129-40.

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