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SNAP-94847 hydrochloride

Chemical Structure : SNAP-94847 hydrochloride

CAS No.: 1781934-47-1

SNAP-94847 hydrochloride (SNAP94847 hydrochloride)

Catalog No.: PC-61526Not For Human Use, Lab Use Only.

SNAP-94847 hydrochloride is a selective, high-affinity, and competitive MCH1 receptor (MCHR1) antagonist with Ki of 1.69 nM.

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Biological Activity

SNAP-94847 hydrochloride is a selective, high-affinity, and competitive MCH1 receptor (MCHR1) antagonist with Ki of 1.69 nM.
SNAP-94847 displays an anxiolytic/antidepressant-like effect in mouse models, stimulates the proliferation of progenitors in the dentate gyrus.
SNAP-94847 has a unique anxiolytic-like profile that is distinct from selective serotonin reuptake inhibitors and tricyclic antidepressants.

 

Physicochemical Properties

M.Wt 515.042
Formula C29H32F2N2O2.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide hydrochloride

References

1. David DJ, et al. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48.

2. Chen CA, et al. J Med Chem. 2007 Aug 9;50(16):3883-90.

3. Nair SG, et al. Psychopharmacology (Berl). 2009 Jul;205(1):129-40.

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