SNAP 37889 (HT-2157) | GalR3 antagonist

Chemical Structure : SNAP 37889

CAS No.: 303149-14-6

SNAP 37889 (HT-2157, HT2157, SNAP37889, SNAP-37889)

Catalog No.: PC-42234Not For Human Use, Lab Use Only.

SNAP 37889 (HT-2157) is a potent, selective galanin-3 receptor (GalR3) antagonist with Ki of 17.44 nM, displays highly selective for Gal3 over the Gal1 and Gal2 subtypes (both Ki >10 uM).

Packing	Price	Stock
5 mg	$228	In stock
10 mg	$378	In stock
25 mg	$598	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

SNAP 37889 (HT-2157) is a potent, selective galanin-3 receptor (GalR3) antagonist with Ki of 17.44 nM, displays highly selective for Gal3 over the Gal1 and Gal2 subtypes (both Ki >10 uM).
SNAP 37889 (HT-2157) attenuates stress-induced hyperthermia in mice, partially antagonizes the galanin-evoked reduction in hippocampal serotonin, exhibits anxiolytic- and antidepressant-like profiles in vivo.

Physicochemical Properties

M.Wt	366.3359
Formula	C21H13F3N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-

References

1. Swanson CJ, et al. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.

2. Ash BL, et al. Regul Pept. 2011 Jan 17;166(1-3):59-67.

3. Koller A, et al. Neuropeptides. 2016 Apr;56:83-8.

4. Scheller KJ, et al. Neuropharmacology. 2017 May 15;118:1-12.

SNAP 37889 (HT-2157, HT2157, SNAP37889, SNAP-37889)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.