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SNIPER(ABL)-062

Chemical Structure : SNIPER(ABL)-062

CAS No.: 2140260-89-3

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SNIPER(ABL)-062 (SNIPER ABL 062)

Catalog No.: PC-60121Not For Human Use, Lab Use Only.

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.
    SNIPER(ABL)-062 shows desirable binding affinities against ABL1, cIAP1/2, and XIAP (IC50=80-500 nM).
    SNIPER(ABL)-062  inhibits BCR-ABL-mediated signaling pathways and CML proliferation in cells expressing BCR-ABL.

    Physicochemical Properties

    M.Wt 1089.655
    Formula C53H63ClF2N10O9S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-((2-(2-(2-(3-(2-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)thiazole-4-carbonyl)phenoxy)ethoxy)ethoxy)ethyl)carbamoyl)pyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide

    References

    1. Shimokawa K, et al. ACS Med Chem Lett. 2017 Sep 14;8(10):1042-1047.

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