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Chemical Structure : SNIPER(AR)-51
Catalog No.: PC-70206Not For Human Use, Lab Use Only.
SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.
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SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.
SNIPER(AR)-51 induces proteasomal degradation of AR and shows effective protein knockdown activity.
SNIPER(AR)-51 inhibits AR-mediated gene expression and proliferation of androgen-dependent prostate cancer cells, and efficiently induces caspase activation and apoptosis in prostate cancer cells.
| M.Wt | 984.226 | |
| Formula | C55H65N7O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.
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