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Chemical Structure : SNIPER(ER)-110
Catalog No.: PC-35090Not For Human Use, Lab Use Only.
SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells.
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SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells.
SNIPER(ER)-110 inhibits the growth of MCF-7 tumor xenografts in mice more potently than the previously characterized SNIPER(ER)-87, preferentially recruits XIAP, rather than cIAP1, to degrade ERα.
| M.Wt | 1122.414 | |
| Formula | C66H83N5O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ohoka N, et al. J Biol Chem. 2018 May 4;293(18):6776-6790.
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