Chemical Structure : SNJ-1945
CAS No.:
854402-59-8
SNJ-1945
(Mitucapistat, SNJ1945)
Catalog No.: PC-26341Not For Human Use, Lab Use Only.
Mitucapistat (SNJ-1945) is potent, selective, reversible and orally available calpain inhibitor with IC50 of 86-190 nM range for m- and μ-calpain.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Mitucapistat (SNJ-1945) is potent, selective, reversible and orally available calpain inhibitor with IC50 of 86-190 nM range for m- and μ-calpain.
SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells.
SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ and Rotenone.
SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis.
Physicochemical Properties
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M.Wt
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491.59
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Formula
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C25H37N3O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
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References
1. Shimazawa M, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):380-7.
2. Koumura A, et al. Neuroscience. 2008 Nov 19;157(2):309-18.
3. Cuerrier D, et al. Biochemistry. 2006 Jun 20;45(24):7446-52.
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