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SOMG-833

Chemical Structure : SOMG-833

CAS No.: 1268264-10-3

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SOMG-833 (Zgwatinib, SOMG833)

Catalog No.: PC-60656Not For Human Use, Lab Use Only.

SOMG833 (Zgwatinib) is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SOMG833 (Zgwatinib) is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.
    SOMG833 displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL.
    SOMG833 significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest.
    SOMG833 demonstrates remarkable antitumor efficacy in vivo.

    Physicochemical Properties

    M.Wt 445.446
    Formula C22H22F3N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-methylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl) quinoline

    References

    1. Zhang HT, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45.

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