SP108 | HDAC3 inhibitor | Probechem Biochemicals

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Chemical Structure : SP108

SP108 (SP-108)

Catalog No.: PC-26710Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SP108 is a potent, selective and brain-permeable HDAC3 inhibitor with IC50 of 15.41 nM, shows 18.72-, 34.65-, >100-, >1000-, >1000-, and >1000-fold selectivity over HDAC1, HDAC2, HDAC8, HDAC6, HDAC4, and HDAC5, respectively.
SP108 treatment improved psychostimulant-induced hyperlocomotion and learning in MAM-exposed rodents.
SP108 treatment in MAM-induced psychotic rats increased acetylated histone levels in the hippocampus.
SP108 treatment in MAM-induced psychotic rats increased levels of memory markers in the hippocampus.

Physicochemical Properties

M.Wt	269.35
Formula	C16H19N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(phenylamino)-N'-propylbenzohydrazide

References

1. Ghosh A, et al. Neuropharmacology. 2026 Apr 30;295:110999.

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SP108 (SP-108)

Biological Activity

Physicochemical Properties

References

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