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Chemical Structure : SPH3127
Catalog No.: PC-49361Not For Human Use, Lab Use Only.
SPH3127 (SPH-3127) is a highly potent, selective and orally active renin inhibitor with IC50 of 0.4 and 0.45 nM for rh-renin and hPRA, respectively.
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SPH3127 (SPH-3127) is a highly potent, selective and orally active renin inhibitor with IC50 of 0.4 and 0.45 nM for rh-renin and hPRA, respectively.
SPH3127 demonstrated higher bioavailability and a more potent antihypertensive effect in preclinical models than aliskiren.
| M.Wt | 444.536 | |
| Formula | C22H32N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Iijima D, et al. J Med Chem. 2022 Aug 25;65(16):10882-10897.
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