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SPH3127

Chemical Structure : SPH3127

CAS No.: 1399849-02-5

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SPH3127 (Sitokiren, SPH-3127)

Catalog No.: PC-49361Not For Human Use, Lab Use Only.

SPH3127 (Sitokiren, SPH-3127) is a highly potent, selective and orally active renin inhibitor with IC50 of 0.4 and 0.45 nM for rh-renin and hPRA, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SPH3127 (Sitokiren, SPH-3127) is a highly potent, selective and orally active renin inhibitor with IC50 of 0.4 and 0.45 nM for rh-renin and hPRA, respectively.
SPH3127 demonstrated higher bioavailability and a more potent antihypertensive effect in preclinical models than aliskiren.

Physicochemical Properties

M.Wt 444.536
Formula C22H32N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (3-(3-((R)-1-((R)-N-cyclopropylmorpholine-2-carboxamido)ethyl)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate

References

1. Iijima D, et al. J Med Chem. 2022 Aug 25;65(16):10882-10897.

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