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SPL-334

Chemical Structure : SPL-334

CAS No.: 688347-51-5

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SPL-334

Catalog No.: PC-24312Not For Human Use, Lab Use Only.

SPL-334 is a selective inhibitor of S-nitrosoglutathione reductase (GSNOR) with KD of 2.0 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SPL-334 is a selective inhibitor of S-nitrosoglutathione reductase (GSNOR) with KD of 2.0 uM.
SPL-334 caused a marked reduction in airway hyperreactivity, allergen-specific T cells and eosinophil accumulation, and mucus production in the lungs in response to allergen inhalation.
SPL-334 treatment resulted in a significant decrease in the production of the Th2 cytokines IL-5 and IL-13 and the level of the chemokine CCL11 (eotaxin-1) in the airways. 

Physicochemical Properties

M.Wt 433.50
Formula C22H15N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid

References

1. Sanghani PC, et al. J Biol Chem 284: 24354–24362.

2. Ferrini ME, et al. PLoS One. 2013 Jul 25;8(7):e70351.

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