Catalog No.: PC-62267Not For Human Use, Lab Use Only.
SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP.
SPV106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP.
SPV106 significantly increases the H3 acetylation level in U937 cells, but no detectable effect on the acetylation level of the non-histone substrate a-tubulin.
SPV106 restores normal levels of H3K9Ac and H3K14Ac, reduces DNA CpG hypermethylation, and recovers D-CMSC proliferation and differentiation.
SPV106 enhances memory for fear extinction and prevents fear renewal in mice.
Physicochemical Properties
M.Wt
310.435
Formula
C18H30O42
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Pentadecylidenemalonate 1b
References
1. Sbardella G, et al. Bioorg Med Chem Lett. 2008 May 1;18(9):2788-92.
2. Wei W, et al. J Neurosci. 2012 Aug 29;32(35):11930-41.
3. Vecellio M, et al. Diabetes. 2014 Jun;63(6):2132-47.
4. Castellano S, et al. ChemMedChem. 2015 Jan;10(1):144-57.
