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SPX-101

Chemical Structure : SPX-101

CAS No.: 2219362-20-4

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SPX-101 (SPX101;SPX 101)

Catalog No.: PC-63534Not For Human Use, Lab Use Only.

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits.
    SPX-101 promotes durable reduction of ENaC membrane concentration, increases mucus transport in the β-ENaC mouse model as well as the sheep model of CF.

    Physicochemical Properties

    M.Wt 1179.385
    Formula C53H90N14O16
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    D-Ala-D-Ala-Leu-Pro-Ile-Pro-Leu-Asp-Gln-Thr-D-Ala-D-Ala-NH2

    References

    1. Scott DW, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744.

    2. Lennox A, et al. Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672.

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