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SQ31f

Chemical Structure : SQ31f

CAS No.: 2083621-48-9

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SQ31f

Catalog No.: PC-23455Not For Human Use, Lab Use Only.

SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase, inhibits ATP hydrolysis with IC50 of 0.6 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase, inhibits ATP hydrolysis with IC50 of 0.6 uM.
SQ31f blocks ATP synthesis ~10 times more potently than ATP hydrolysis, binds a previously unknown site in the enzyme's proton‐conducting channel.
SQ31f has shown a promising ability to arrest the growth of M. tuberculosis in a mouse model of TB.

Physicochemical Properties

M.Wt 349.39
Formula C20H19N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-Morpholinophenyl)-4-((pyridin-2-ylmethyl)amino)cyclobut-3-ene-1,2-dione

References

1. Courbon GM, et al. EMBO J. 2023 Aug 1;42(15):e113687.

2. Ragunathan P, et al. J Antimicrob Chemother. 2024 Nov 5:dkae406.

3. Tantry SJ, et al. J Med Chem 60: 1379–1399

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