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SR-16507

Chemical Structure : SR-16507

CAS No.: 1207195-44-5

SR-16507 (SR16507)

Catalog No.: PC-61539Not For Human Use, Lab Use Only.

SR-16507 is a potent full agonist of ORL1 receptor (NOP receptor) and partial agonist of mu-opioid receptor with Ki of 5.22 nM and 1.07 nM, respectively.

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    Biological Activity

    SR-16507 is a potent full agonist of ORL1 receptor (NOP receptor) and partial agonist of mu-opioid receptor with Ki of 5.22 nM and 1.07 nM, respectively.
    SR-16507  is a potent analgesic and produces conditioned place preference (CPP) alone, but also modestly attenuates morphine CPP; demonstrates antinociceptive effects in vivo.

    Physicochemical Properties

    M.Wt 368.565
    Formula C24H36N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-ethyl-1-(1-((1s,4s)-4-isopropylcyclohexyl)piperidin-4-yl)indolin-2-one

    References

    1. Toll L, et al. J Pharmacol Exp Ther. 2009 Dec;331(3):946-53.

    2. Khroyan TV, et al. J Pharmacol Exp Ther. 2009 Dec;331(3):946-53.

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