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SR-16835

Chemical Structure : SR-16835

CAS No.: 1207195-45-6

SR-16835 (SR16835)

Catalog No.: PC-61540Not For Human Use, Lab Use Only.

SR-16835 is a potent full agonist of ORL1 receptor (NOP receptor) with binding Ki of 11.4 nM, with low-affinity mu-opioid partial agonist activity (Ki=79.9 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SR-16835 is a potent full agonist of ORL1 receptor (NOP receptor) with binding Ki of 11.4 nM, with low-affinity mu-opioid partial agonist activity (Ki=79.9 nM).
    SR-16835 does not produce conditioned place preference (CPP) alone, but attenuates morphine CPP.
    SR-16835 shows antiallodynic activity in mice model of chronic pain.

    Physicochemical Properties

    M.Wt 386.54
    Formula C26H30N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-[1-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-4-piperidinyl]-1,3-dihydro-2H-indol-2-one

    References

    1. Toll L, et al. J Pharmacol Exp Ther. 2009 Dec;331(3):946-53.

    2. Khroyan TV, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):687-93.

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