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Chemical Structure : SR-18292
CAS No.: 2095432-55-4
Catalog No.: PC-62696Not For Human Use, Lab Use Only.
SR-18292 (SR18292) is a potent PGC-1α inhibitor, increases PGC-1α acetylation, suppresses gluconeogenic gene expression, and reduce glucose production in hepatocytes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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SR-18292 (SR18292) is a potent PGC-1α inhibitor, increases PGC-1α acetylation, suppresses gluconeogenic gene expression, and reduce glucose production in hepatocytes.
SR-18292 increases the interaction of PGC-1α with GCN5 and reduces transcriptional activity of HNF4α.
SR-18292 reduces fasting blood glucose, increases hepatic insulin sensitivity, and improves glucose homeostasis in diabetic mice.
| M.Wt | 366.5 | |
| Formula | C23H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-2-propanol |
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1. Sharabi K, et al. Cell. 2017 Mar 23;169(1):148-160.e15.
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