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Chemical Structure : SR-3029
CAS No.: 1454585-06-8
Catalog No.: PC-42026Not For Human Use, Lab Use Only.
SR-3029 is a potent, highly selective, ATP-competitive and brain penetrating Casein Kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 44/260 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SR-3029 is a potent, highly selective, ATP-competitive and brain penetrating Casein Kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 44/260 nM, respectively.
SR-3029 inhibits melanoma A375 cell growth with IC50 of 86 nM.
SR-3029 triggers apoptosis of CK1δ-expressing breast tumor cells ex vivo, tumor regression in orthotopic models of triple-negative breast cancer in mice model.
| M.Wt | 480.4452 | |
| Formula | C23H19F3N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)- |
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1. Bibian M, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.
2. Rosenberg LH, et al. Sci Transl Med. 2015 Dec 16;7(318):318ra202.
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