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SR-3029

Chemical Structure : SR-3029

CAS No.: 1454585-06-8

SR-3029 (SR3029)

Catalog No.: PC-42026Not For Human Use, Lab Use Only.

SR-3029 is a potent, highly selective, ATP-competitive and brain penetrating Casein Kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 44/260 nM, respectively.

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Biological Activity

SR-3029 is a potent, highly selective, ATP-competitive and brain penetrating Casein Kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 44/260 nM, respectively.
SR-3029 inhibits melanoma A375 cell growth with IC50 of 86 nM.
SR-3029 triggers apoptosis of CK1δ-expressing breast tumor cells ex vivo, tumor regression in orthotopic models of triple-negative breast cancer in mice model.

Physicochemical Properties

M.Wt 480.4452
Formula C23H19F3N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

9H-Purin-6-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-morpholinyl)-

References

1. Bibian M, et al. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.

2. Rosenberg LH, et al. Sci Transl Med. 2015 Dec 16;7(318):318ra202.

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