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Chemical Structure : SR-3306
CAS No.: 1128096-91-2
Catalog No.: PC-43238Not For Human Use, Lab Use Only.
SR-3306 (SR3306) is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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SR-3306 (SR3306) is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38.
SR-3306 shows cell-based IC50 of 216 nM, protects dopaminergic neurons against MPTP neurotoxicity in vitro and in vivo, achieves dopaminergic neuronal survival in the 6-OHDA model.
SR-3306 also prevents ROS increases and mitochondrial dysfunction.
| M.Wt | 490.5591 | |
| Formula | C28H26N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrimidinamine, N-[4-[3-(6-methyl-3-pyridinyl)-1H-1,2,4-triazol-1-yl]phenyl]-4-[3-(4-morpholinyl)phenyl]- |
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1. Crocker CE, et al. ACS Chem Neurosci. 2011 Apr 20;2(4):207-212.
2. Chambers JW, et al. J Biol Chem. 2013 Feb 8;288(6):4000-11.
3. Gao S, et al. Sci Rep. 2017 Feb 6;7:41795.
4. Chambers JW, et al. ACS Chem Neurosci. 2011 Apr 20;2(4):198-206.
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