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Chemical Structure : SR-4133
Catalog No.: PC-20823Not For Human Use, Lab Use Only.
SR-4133 (SR4133) is a potent and highly selective CK1ε isoform inhibitor with IC50 of 58 nM, no significant acitivity agianst CK1δ (IC50>10,000 nM).
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SR-4133 (SR4133) is a potent and highly selective CK1ε isoform inhibitor with IC50 of 58 nM, no significant acitivity agianst CK1δ (IC50>10,000 nM).
SR-4133 blocks the phosphorylation of T37/46, S65, and T70 of 4E-BP1 in T24 cells.
SR-4133 displays nanomolar growth inhibition of bladder cancer cells and inhibit the phosphorylation of 4E-BP1 in T24 cells, which is a direct downstream effector of CK1ε.
| M.Wt | 512.52 | |
| Formula | C27H22F2N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jun Yong Choi, et al. J Med Chem. 2023 May 19. doi: 10.1021/acs.jmedchem.2c01180.
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