SR-4133 | CK1ε inhibitor | Probechem Biochemicals

Chemical Structure : SR-4133

SR-4133 (SR4133)

Catalog No.: PC-20823Not For Human Use, Lab Use Only.

SR-4133 (SR4133) is a potent and highly selective CK1ε isoform inhibitor with IC50 of 58 nM, no significant acitivity agianst CK1δ (IC50>10,000 nM).

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Biological Activity

SR-4133 (SR4133) is a potent and highly selective CK1ε isoform inhibitor with IC50 of 58 nM, no significant acitivity agianst CK1δ (IC50>10,000 nM).
SR-4133 blocks the phosphorylation of T37/46, S65, and T70 of 4E-BP1 in T24 cells.
SR-4133 displays nanomolar growth inhibition of bladder cancer cells and inhibit the phosphorylation of 4E-BP1 in T24 cells, which is a direct downstream effector of CK1ε.

Physicochemical Properties

M.Wt	512.52
Formula	C27H22F2N8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	FC1=CC=C2NC(CNC3=C4N=CN(C5=CC=C6C=CC=CC6=C5)C4=NC(N7CCOCC7)=N3)=NC2=C1F

References

1. Jun Yong Choi, et al. J Med Chem. 2023 May 19. doi: 10.1021/acs.jmedchem.2c01180.

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SR-4133 (SR4133)

Biological Activity

Physicochemical Properties

References

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