SR-8993 is a potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM.
SR-8993 dispalys a high selectivity (>100-fold) for NOP-R over the closely related opioid receptors (μ/κ/δ).
SR-8993 prevents fear memory consolidation when injected into the central amygdala or systemically in PTSD-like model.
SR-8993 potently reverses acute alcohol withdrawal-induced anxiety with mildly anxiolytic effect in rats.
