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Chemical Structure : SR-8993
Catalog No.: PC-61596Not For Human Use, Lab Use Only.
A potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM.
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A potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM; dispalys a high selectivity (>100-fold) for NOP-R over the closely related opioid receptors (μ/κ/δ); prevents fear memory consolidation when injected into the central amygdala or systemically in PTSD-like model; potently reverses acute alcohol withdrawal-induced anxiety with mildly anxiolytic effect in rats.
| M.Wt | 412.597 | |
| Formula | C25H37FN4 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Andero R, et al. Sci Transl Med. 2013 Jun 5;5(188):188ra73.
2. Sartor GC, et al. Brain Res. 2016 Feb 1;1632:34-41.
3. Aziz AM, et al. Psychopharmacology (Berl). 2016 Oct;233(19-20):3553-63.
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