Catalog No.: PC-35769Not For Human Use, Lab Use Only.
SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.
SR12343 (SR-12343) is a novel small molecule that inhibits IKK/NF-κB activation by disrupting the association between IKKβ and NEMO.
SR12343 inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.
SR12343 acted as a NEMO-binding domain mimetic and a highly selective inhibitor of the IKK complex by disrupting the association of IKKβ and the IKKγ subunit NEMO.
SR-12343 inhibited tumor necrosis factor α (TNF-α)- and lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO and suppressed LPS-induced acute pulmonary inflammation in mice.
