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Chemical Structure : SR12343
CAS No.: 2055101-86-3
Catalog No.: PC-35769Not For Human Use, Lab Use Only.
SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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SR12343 (SR-12343) is a novel small molecule that inhibits IKK/NF-κB activation by disrupting the association between IKKβ and NEMO.
SR12343 inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.
SR12343 acted as a NEMO-binding domain mimetic and a highly selective inhibitor of the IKK complex by disrupting the association of IKKβ and the IKKγ subunit NEMO.
SR-12343 inhibited tumor necrosis factor α (TNF-α)- and lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO and suppressed LPS-induced acute pulmonary inflammation in mice.
| M.Wt | 368.659 | |
| Formula | C15H15BrClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide |
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1. Zhao J, et al. PLoS Biol. 2018 Jun 11;16(6):e2004663.
2. Zhang L, et al. Aging Cell. 2021 Dec;20(12):e13486.
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