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Chemical Structure : SR140333B
Catalog No.: PC-22655Not For Human Use, Lab Use Only.
Nolpitantium besilate (SR140333B) is a potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM.
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Nolpitantium besilate (SR140333B) is a potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM.
Nolpitantium (SR140333) shows no effect in bioassays for NK2 and NK3 receptors.
Nolpitantium (SR140333) blocks substance P-induced release of acetylcholine from rat striatum, exerts highly potent antagonism toward substance P-induced hypotension in vivo.
Nolpitantium (SR140333) also blocks the activation of rat thalamic neurons after nociceptive stimulation.
| M.Wt | 777.84 | |
| Formula | C43H50Cl2N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emonds-Alt X, et al. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.
2. Jung M, et al. Neuropharmacology. 1994 Feb;33(2):167-79.
3. Oury-Donat F, et al. J Neurochem. 1994 Apr;62(4):1399-407.
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