Chemical Structure : SR140333B
CAS No.:
155418-06-7
SR140333B
(SR-140333B, Nolpitantium besilate)
Catalog No.: PC-22655Not For Human Use, Lab Use Only.
Nolpitantium besilate (SR140333B) is a potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Nolpitantium besilate (SR140333B) is a potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM.
Nolpitantium (SR140333) shows no effect in bioassays for NK2 and NK3 receptors.
Nolpitantium (SR140333) blocks substance P-induced release of acetylcholine from rat striatum, exerts highly potent antagonism toward substance P-induced hypotension in vivo.
Nolpitantium (SR140333) also blocks the activation of rat thalamic neurons after nociceptive stimulation.
Physicochemical Properties
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M.Wt
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777.84
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Formula
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C43H50Cl2N2O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Azoniabicyclo[2.2.2]octane, 1-[2-[(3S)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-, benzenesulfonate (1:1)
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References
1. Emonds-Alt X, et al. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.
2. Jung M, et al. Neuropharmacology. 1994 Feb;33(2):167-79.
3. Oury-Donat F, et al. J Neurochem. 1994 Apr;62(4):1399-407.
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