SR 16157 (NSC 732011, HLX 801) | Steroid sulfatase inhibitor, SERM

Chemical Structure : SR 16157

SR 16157 (NSC 732011, SR16157, HLX 801)

Catalog No.: PC-61433Not For Human Use, Lab Use Only.

SR 16157 (NSC 732011, HLX 801) is a dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM).

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Biological Activity

SR 16157 (NSC 732011, HLX 801) is a dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM).
SR 16157 exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells.
SR 16157 displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes.

Physicochemical Properties

M.Wt	492.719
Formula	C27H44N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7R,17R)-17-(2-(2-(diethylamino)ethoxy)ethyl)-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl sulfamate

References

1. Rasmussen LM, et al. Breast Cancer Res Treat. 2007 Dec;106(2):191-203.

2. Rausch L, et al. Cancer Chemother Pharmacol. 2011 Jun;67(6):1341-52.

3. Wang J, et al. J Pharm Biomed Anal. 2007 Nov 30;45(4):572-82.

SR 16157 (NSC 732011, SR16157, HLX 801)

Biological Activity

Physicochemical Properties

References

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