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Chemical Structure : SR18662
CAS No.: 2505001-62-5
Catalog No.: PC-73043Not For Human Use, Lab Use Only.
SR18662 (SR 18662) is a small-molecule compound that inhibits KLF5 (IC50=4.4 nM), inhibits growth of colorectal cancer in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SR18662 (SR 18662) is a small-molecule compound that inhibits KLF5 (IC50=4.4 nM), inhibits growth of colorectal cancer in vitro and in vivo.
SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. SR18662 showed an increase in cells captured in either S or G2-M phases of the cell cycle and a significant increase in the number of apoptotic cells, the latter a unique property compared with ML264 or SR15006.
SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways. dose-dependent inhibition of xenograft growth in mice following SR18662 treatment that exceeded the effect of ML264 at equivalent doses.
| M.Wt | 420.305 | |
| Formula | C16H19Cl2N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide |
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1. Julie Kim, et al. Mol Cancer Ther. 2019 Nov;18(11):1973-1984.
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