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Chemical Structure : SR 48692
Catalog No.: PC-60947Not For Human Use, Lab Use Only.
A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity.
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A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity; blocks K(+)-evoked release of [3H]dopamine stimulated by neurotensin in guinea pig striatal slices with IC50 of 0.46 nM, competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization with pA2 of 8.13 in H29 cells; reverses the turning behavior induced by intrastriatal injection of neurotensin in mice.
Lung Cancer
Phase 2 Clinical
| M.Wt | 587.073 | |
| Formula | C32H31ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dubuc I, et al. Br J Pharmacol. 1994 Jun;112(2):352-4.
2. Steinberg R, et al. Neuroscience. 1994 Apr;59(4):921-9.
3. Brouard A, et al. Eur J Pharmacol. 1994 Mar 3;253(3):289-91.
4. Gully D, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):65-9.
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