Catalog No.: PC-60947Not For Human Use, Lab Use Only.
SR48692 (Meclinertant) is a potent, selective and orally active nonpeptide antagonist of neurotensin receptor NTSR1 with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity.
SR48692 (Meclinertant) is a potent, selective and orally active nonpeptide antagonist of neurotensin receptor NTSR1 with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity.
SR48692 (Meclinertant) blocks K(+)-evoked release of [3H]dopamine stimulated by neurotensin in guinea pig striatal slices with IC50 of 0.46 nM, competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization with pA2 of 8.13 in H29 cells.
SR48692 (Meclinertant) reverses the turning behavior induced by intrastriatal injection of neurotensin in mice.
