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SR9883

Chemical Structure : SR9883

CAS No.: 1245812-72-9

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SR9883 (SR-9883)

Catalog No.: PC-23179Not For Human Use, Lab Use Only.

SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs.
SR9883 shows EC50 of 0.2-0.4 uM for markedly enhancing the response on HEK cells stably expressing (α4)2(β2)2β2/α4 (α4β2*), (α4)2(β2)2α5, or (α4)2(β2)2β3 nAChRs.
SR9883 (0, 5, or 10 mg/ kg) enhances the locomotor-suppressant effects of nicotine in mice.
SR9883 enhances the reward-inhibiting effects of nicotine in mice, decreases nicotine intake in rats.

Physicochemical Properties

M.Wt 248.25
Formula C13H8N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile

References

1. Braunscheidel KM, et al. Front Mol Neurosci. 2024 Sep 5;17:1459098.

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