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SRI-31142

Chemical Structure : SRI-31142

CAS No.: 1940118-04-6

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SRI-31142 (SRI31142)

Catalog No.: PC-35618Not For Human Use, Lab Use Only.

SRI-31142 (SRI31142) is a novel potent, putative allosteric dopamine transporter (DAT) inhibitor with Ki of 1.9 nM..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SRI-31142 (SRI31142) is a potent, putative allosteric dopamine transporter (DAT) inhibitor with Ki of 1.9 nM.
    SRI-31142 does not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses.
    SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine.

    Physicochemical Properties

    M.Wt 456.553
    Formula C29H24N6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(7-Methylimidazo[1,2-a]pyridin-6-yl)-N-(2-phenyl-2-(pyridin-4-yl)ethyl)quinazolin-4-amine

    References

    1. Moerke MJ, et al. J Pharmacol Exp Ther. 2018 Aug 27. pii: jpet.118.250902.

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