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Chemical Structure : SRI-32743
Catalog No.: PC-49495Not For Human Use, Lab Use Only.
SRI-32743 is a novel allosteric modulator of dopamine transporter (DAT), attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter.
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SRI-32743 is a novel allosteric modulator of dopamine transporter (DAT), attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter.
SRI-32743 shares the binding residues inside the pocket of DAT with Tat binding.
SRI-32743 (50 nM) attenuated Tat-induced inhibition of [3H]DA uptake and decreased the cocaine-mediated dissociation of [3H]WIN35,428 binding in CHO cells expressing hDAT.
SRI-32743 ameliorates Tat-induced cognitive deficits and potentiation of cocaine reward.
SRI-32743 reverses HIV-1 Tat-induced increase in dopamine release in the caudate putamen of inducible Tat transgenic mice.
| M.Wt | 407.52 | |
| Formula | C26H25N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Davis SE, et al. J Pharmacol Exp Ther. 2022 Dec 1:JPET-AR-2022-001291.
2. Jun Zhu, et al. Neuropharmacology. 2022 Dec 1;220:109239.
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