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SRI-41897

Chemical Structure : SRI-41897

CAS No.: 1208824-23-0

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SRI-41897 (SRI41897)

Catalog No.: PC-38494Not For Human Use, Lab Use Only.

SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.
    SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).
    SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs).

    Physicochemical Properties

    M.Wt 279.247
    Formula C13H11F2N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2,4-difluorobenzyl)-N-methyl-5-nitropyridin-2-amine

    References

    1. Carolyn A Robinson, et al. Viruses. 2022 Apr 15;14(4):817.

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