SRK2128 | HMGCR degrader | Probechem Biochemicals

Chemical Structure : SRK2128

Catalog No.: PC-49777Not For Human Use, Lab Use Only.

SRK2128 (SRK 2128) is a highly potent HMG-CoA reductase degrader with EC50 of 84 nM, potently induce degradation of HMG-CoA reductase.

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Biological Activity

SRK2128 (SRK 2128) is a highly potent HMG-CoA reductase degrader with EC50 of 84 nM, potently induce degradation of HMG-CoA reductase.

M.Wt	583.63
Formula	C27H49F2NO6P2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tetraisopropyl (2-(2,6-bis(1-fluoro-2-methylpropan-2-yl)pyridin-4-yl)ethane-1,1-diyl)bis(phosphonate)

1. Kawamura K, et al. Bioorg Med Chem. 2023 Jan 15;78:117145.