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Chemical Structure : SSTC3
CAS No.: 1242422-09-8
Catalog No.: PC-60387Not For Human Use, Lab Use Only.
SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM.
SSTC3 has better pharmacokinetic properties than pyrvinium (Cat# PC-60383), attenuates the growth of such Apc mutant organoids with EC50 of 2.9 uM.
SSTC3 decreases the viability of the WNT-dependent cell lines (EC50 = 132, 63, and 123 nM for HT29, SW403, and HCT116 cells, respectively), inhibits the growth of CRC xenografts in mice.
SSTC3 also attenuates the growth of patient-derived metastatic CRC xenograft, with minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.
| M.Wt | 518.529 | |
| Formula | C23H17F3N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamide |
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1. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.
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