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ST-168

Chemical Structure : ST-168

CAS No.: 2126038-25-1

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ST-168 (ST168)

Catalog No.: PC-61741Not For Human Use, Lab Use Only.

ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.
    ST-168 exhibits improved inhibition toward PI3K isoforms compared to ST-162.
    ST-168 demonstrates superior tumoricidal efficacy over ST-162 in an A375 melanoma spheroid tumor model.

    Physicochemical Properties

    M.Wt 1010.762
    Formula C41H44F5IN10O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-(2-(2-(3-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

    References

    1. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813.

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